Abstract | BACKGROUND: METHODS:
Liposomes composed of egg phosphatidylcholine were prepared by Bangham's method. Storage stability of phthalocyanine-loaded liposomes was evaluated at 30 and 60 days after preparation. For the in vivo evaluation, the animals were infected with L. (L.) amazonensis and divided into groups: chloroaluminium phthalocyanine-loaded liposome, blank liposome, meglumine antimoniate (200 mgSb+5/Kg/day), and control. The lesion size was determined weekly after the beginning of the treatment. Upon completion, parasites were recovered from the skin lesion and spleen and evaluated by limiting dilution assay. RESULTS: CONCLUSIONS:
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Authors | Sávia Caldeira Lopes, Raphaela Ariany Silva, Marcus Vinícius Novais, Larissa Dutra Coelho, Lucas Antônio Ferreira, Paulo Eduardo Souza, Antônio Tedesco, Ricardo Bentes Azevedo, Marta Gontijo Aguiar, Mônica Cristina Oliveira |
Journal | Photodiagnosis and photodynamic therapy
(Photodiagnosis Photodyn Ther)
Vol. 28
Pg. 210-215
(Dec 2019)
ISSN: 1873-1597 [Electronic] Netherlands |
PMID | 31454712
(Publication Type: Journal Article)
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Copyright | Copyright © 2019 Elsevier B.V. All rights reserved. |
Chemical References |
- Indoles
- Liposomes
- Organometallic Compounds
- Photosensitizing Agents
- chloroaluminum phthalocyanine
- Antimony
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Topics |
- Administration, Topical
- Animals
- Antimony
(administration & dosage)
- Indoles
(administration & dosage)
- Leishmaniasis, Cutaneous
(drug therapy)
- Liposomes
- Mesocricetus
- Mice, Inbred BALB C
- Organometallic Compounds
(administration & dosage)
- Photochemotherapy
(methods)
- Photosensitizing Agents
(administration & dosage)
- Spleen
(parasitology)
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