Relative cross reactivity of habanin, lepromin and tuberculin in guinea pigs sensitized with homologous and heterologous mycobacteria.

Abstract

An atypical strain Mycobacterium habana has been studied for its antigenic cross reactivity with delayed type of hypersensitivity responses in guinea pigs. Guinea pigs sensitized with M. habana, M. leprae and M. tuberculosis when challenged with habanin, lepromin and tuberculin in criss-cross fashion have demonstrated strong cross reactivity with each other. Possibilities of developing M. habana as a vaccine against tuberculosis and/or leprosy has been discussed.

• Authors: N B Singh, A Srivastava, H P Gupta, A Kumar, V K Chaturvedi
• Journal: Indian journal of leprosy (Indian J Lepr) Vol. 60 Issue 3 Pg. 407-12 (Jul 1988) ISSN: 0254-9395 [Print] India
• PMID: 3143770 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antigens, Bacterial
• Tuberculin
• Vaccines, Attenuated
• habanin
• Lepromin

Topics

• Animals
• Antigens, Bacterial (immunology)
• Cross Reactions
• Guinea Pigs
• Hypersensitivity, Delayed (immunology)
• Lepromin (immunology)
• Mycobacterium (immunology)
• Mycobacterium leprae (immunology)
• Mycobacterium tuberculosis (immunology)
• Nontuberculous Mycobacteria (classification, immunology)
• Skin Tests
• Tuberculin (immunology)
• Vaccines, Attenuated (immunology)