Comparative in vitro activity of the two new 4-quinolones S-25930 and S-25932 against gram-positive bacteria isolated from cancer patients.

Abstract

The in vitro activity of S-25930 and S-25932, two new quinolone antimicrobial agents, against 306 gram-positive organisms representing 12 bacterial species, was evaluated and compared with the activity of ciprofloxacin, difloxacin, enoxacin, amifloxacin and A-56620. Both agents were active against staphylococcal species (including methicillin-resistant and coagulase-negative isolates), Bacillus spp. and group JK diphtheroids. They were less active against streptococcal species and Listeria monocytogenes. Their activity against most isolates was superior to that of amifloxacin, enoxacin and difloxacin and similar to that of ciprofloxacin and A-56620.

• Authors: K V Rolston, D H Ho, B LeBlanc, G P Bodey
• Journal: European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology (Eur J Clin Microbiol Infect Dis) Vol. 7 Issue 5 Pg. 681-3 (Oct 1988) ISSN: 0934-9723 [Print] Germany
• PMID: 3143584 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Anti-Bacterial Agents
• Quinolizines
• ibafloxacin
• S 25932

Topics

• Anti-Bacterial Agents (pharmacology)
• Bacillus (drug effects)
• Gram-Positive Bacteria (drug effects, isolation & purification)
• Humans
• Listeria monocytogenes (drug effects)
• Microbial Sensitivity Tests
• Neoplasms (microbiology)
• Quinolizines (pharmacology)
• Staphylococcus (drug effects)
• Streptococcus (drug effects)