Effects of single doses of vigabatrin on CSF concentrations of GABA, homocarnosine, homovanillic acid and 5-hydroxyindoleacetic acid in patients with complex partial epilepsy.

Abstract

Vigabatrin, as a single oral dose of 50 mg/kg, was administered to 11 patients with drug-refractory complex partial epilepsy. Serial lumbar punctures were performed prior to and 5 times within the first week following treatment. Cerebrospinal fluid (CSF) concentrations of total GABA, free GABA, homocarnosine, homovanillic acid (HVA), 5-hydroxyindoleacetic acid (5-HIAA) and vigabatrin were determined as well as blood vigabatrin levels. CSF GABA, homocarnosine, HVA and 5-HIAA concentrations increased by 6 h after the single dose and remained elevated for up to 5-7 days. In contrast, CSF and blood vigabatrin levels were maximal within the first 24 h and were no longer detectable thereafter. Hence, these results are consistent with vigabatrin acting as an irreversible inhibitor of GABA-transaminase and suggest that it may also increase biogenic amine turnover.

• Authors: E B Menachem, L I Persson, P J Schechter, K D Haegele, N Huebert, J Hardenberg, L Dahlgren, J P Mumford
• Journal: Epilepsy research (Epilepsy Res) 1988 Mar-Apr Vol. 2 Issue 2 Pg. 96-101 ISSN: 0920-1211 [Print] Netherlands
• PMID: 3143561 (Publication Type: Journal Article)

Chemical References

• Aminocaproates
• Dipeptides
• Serotonin
• homocarnosine
• gamma-Aminobutyric Acid
• Carnosine
• Vigabatrin
• Homovanillic Acid

Topics

• Administration, Oral
• Adult
• Aminocaproates (administration & dosage, cerebrospinal fluid, therapeutic use)
• Carnosine (analogs & derivatives, cerebrospinal fluid)
• Dipeptides (cerebrospinal fluid)
• Epilepsies, Partial (cerebrospinal fluid, drug therapy)
• Female
• Homovanillic Acid (cerebrospinal fluid)
• Humans
• Male
• Middle Aged
• Serotonin (cerebrospinal fluid)
• Vigabatrin
• gamma-Aminobutyric Acid (cerebrospinal fluid)