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Effects of BW755C, a mixed cyclo-oxygenase-lipoxygenase inhibitor, following traumatic spinal cord injury in rats.

Abstract
BW755C is an inhibitor of both cyclo-oxygenase and lipoxygenase, which has been found to have protective effects after myocardial ischemia in dogs. Impact injury to the spinal cord is associated with tissue ischemia as well as with the accumulation of eicosanoids. In the present studies we evaluated the effects of BW755C after traumatic spinal cord injury in rats. Drug treatment reduced thromboxane B2 levels and improved neurological recovery as compared to treatment with equal-volume physiological saline. The findings suggest that this drug or related compounds may be useful for the treatment of clinical spinal cord injury.
AuthorsA I Faden, M Lemke, P Demediuk
JournalBrain research (Brain Res) Vol. 463 Issue 1 Pg. 63-8 (Oct 25 1988) ISSN: 0006-8993 [Print] Netherlands
PMID3143469 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Enzyme Inhibitors
  • Pyrazoles
  • Thromboxane B2
  • 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine
  • Lipoxygenase
  • Prostaglandin-Endoperoxide Synthases
Topics
  • 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine
  • Animals
  • Enzyme Inhibitors (therapeutic use)
  • Lipoxygenase (metabolism)
  • Prostaglandin-Endoperoxide Synthases (metabolism)
  • Pyrazoles (therapeutic use)
  • Rats
  • Rats, Inbred Strains
  • Spinal Cord Injuries (drug therapy, enzymology, metabolism)
  • Thromboxane B2 (metabolism)

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