[Reaserch Advances on the Role of PI3K/AKT Signaling Pathway and MiRNA in Acute T-Cell Lymphocytic Leukemia--Review].

Abstract

Abstract　　Numerous studies have confirmed that abnormal activation of the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) signaling pathway is one of the most common induction mechanisms of T-ALL. In recent years, many literature report that multiple abnormally expressed microRNAs (miRNAs) can participate in the development of T-ALL by regulating the PI3K/AKT signaling pathway. For example, overexpression of miR-19 and miR181a can activate the PI3K/AKT signaling pathway, which leads to the development of T-ALL and induction of chemotherapy drug resistance, as well as the low expression of miR-26b and miR-29a. Apart from the inhibitors and traditional Chinese medicines that target the PI3K/AKT signaling pathway, regulation of the expression of the corresponding miRNA may also be a potential treatment protocol for T-ALL. The mechanisms of PI3K/AKT signaling pathway involved in the development of T-ALL, the role of miRNAs in the PI3K/AKT signaling pathway and the targeted therapy based on this signaling pathway are summarized briefly in this review.

• Authors: Yong-Jun Li, Xiao-Fei Li, Er-Huan Yang, Min Shi
• Journal: Zhongguo shi yan xue ye xue za zhi (Zhongguo Shi Yan Xue Ye Xue Za Zhi) Vol. 27 Issue 4 Pg. 1344-1347 (Aug 2019) ISSN: 1009-2137 [Print] China
• PMID: 31418405 (Publication Type: Journal Article, Review)

Chemical References

• MicroRNAs
• Phosphatidylinositol 3-Kinases
• Proto-Oncogene Proteins c-akt

Topics

• Humans
• Leukemia, T-Cell
• MicroRNAs
• Phosphatidylinositol 3-Kinases
• Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
• Proto-Oncogene Proteins c-akt
• Signal Transduction