A new immunomodulator, FR-900490.

Abstract

FR-900490 is a new type of immunoactive substance produced by a fungus Discosia sp. F-11809. The colony forming units in culture (cfu-c) in bone marrow cells, which were suppressed by immunosuppressive factor obtained from the serum of sarcoma 180 tumor bearing mouse, was restored to normal level by the addition of FR-900490 in vitro. Furthermore, in mitomycin C (MMC)-treated mice the subsequent administration of FR-900490 caused a significant increase of cfu-c in bone marrow cells depressed by MMC.

• Authors: T Shibata, O Nakayama, M Okuhara, Y Tsurumi, H Terano, M Kohsaka
• Journal: The Journal of antibiotics (J Antibiot (Tokyo)) Vol. 41 Issue 9 Pg. 1163-9 (Sep 1988) ISSN: 0021-8820 [Print] England
• PMID: 3141334 (Publication Type: Journal Article)

Chemical References

• Adjuvants, Immunologic
• Anti-Bacterial Agents
• Mitomycins
• Peptides
• FR 900490
• Mitomycin

Topics

• Adjuvants, Immunologic (isolation & purification)
• Animals
• Anti-Bacterial Agents (isolation & purification)
• Bone Marrow (drug effects)
• Colony-Forming Units Assay
• Female
• In Vitro Techniques
• Mice
• Mice, Inbred ICR
• Mitomycin
• Mitomycins (pharmacology)
• Peptides (isolation & purification, pharmacology)
• Sarcoma 180 (immunology)
• Stem Cells (drug effects)