A new immunomodulator, FR-900490.

FR-900490 is a new type of immunoactive substance produced by a fungus Discosia sp. F-11809. The colony forming units in culture (cfu-c) in bone marrow cells, which were suppressed by immunosuppressive factor obtained from the serum of sarcoma 180 tumor bearing mouse, was restored to normal level by the addition of FR-900490 in vitro. Furthermore, in mitomycin C (MMC)-treated mice the subsequent administration of FR-900490 caused a significant increase of cfu-c in bone marrow cells depressed by MMC.
AuthorsT Shibata, O Nakayama, M Okuhara, Y Tsurumi, H Terano, M Kohsaka
JournalThe Journal of antibiotics (J Antibiot (Tokyo)) Vol. 41 Issue 9 Pg. 1163-9 (Sep 1988) ISSN: 0021-8820 [Print] JAPAN
PMID3141334 (Publication Type: Journal Article)
Chemical References
  • Adjuvants, Immunologic
  • Anti-Bacterial Agents
  • Mitomycins
  • Peptides
  • FR 900490
  • Mitomycin
  • Adjuvants, Immunologic (isolation & purification)
  • Animals
  • Anti-Bacterial Agents (isolation & purification)
  • Bone Marrow (drug effects)
  • Colony-Forming Units Assay
  • Female
  • In Vitro Techniques
  • Mice
  • Mice, Inbred ICR
  • Mitomycin
  • Mitomycins (pharmacology)
  • Peptides (isolation & purification, pharmacology)
  • Sarcoma 180 (immunology)
  • Stem Cells (drug effects)

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