Abstract |
Patients with pathologically defined prostatic carcinoma (114 cases in 23 institutes) were subcutaneously administered 500 micrograms of Buserelin ( Hoe 766) 3 times a day for 7 consecutive days, then randomized to intranasally administered 600 or 900 micrograms/day of Buserelin as maintenance treatment. We examined the clinical efficacy, safety and endocrinological effects of the drug by the intranasal dosage. Size of prostate decreased more than 25% in 21 cases (total 47 cases; measured at the start and 3 months treatment by ultrasonography. Complete response and partial response were observed in 13 cases (16.1%) by NPCP's criteria at 3 months Buserelin treatment. Grobal Improvement Rating (GIR) were respectively 64.3% (600 micrograms group) and 68.0% (900 micrograms group). Grobal Utility Rating ( GUR) were respectively 85.7% (600 micrograms group) and 82.0% (900 micrograms group). No significance was observed in these two groups. Adverse reactions were observed in 21 cases (18.9%). Except in 1 case, they were slight and the Buserelin treatment could be continued. Objectively Safety Rating (OSR) was 92.8%. Five cases were treated for more than 2 years with Buserelin and these cases were well controlled. Buserelin was considered as an effective and safe drug to treat prostatic carcinoma.
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Authors | T Niijima, T Kishimoto, J Shimazaki, O Yoshida, K Isurugi |
Journal | Hinyokika kiyo. Acta urologica Japonica
(Hinyokika Kiyo)
Vol. 34
Issue 7
Pg. 1309-19
(Jul 1988)
ISSN: 0018-1994 [Print] Japan |
PMID | 3140622
(Publication Type: Clinical Trial, English Abstract, Journal Article, Multicenter Study, Randomized Controlled Trial)
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Chemical References |
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Topics |
- Administration, Intranasal
- Aged
- Aged, 80 and over
- Buserelin
(administration & dosage, therapeutic use)
- Drug Evaluation
- Humans
- Male
- Middle Aged
- Multicenter Studies as Topic
- Prognosis
- Prostatic Neoplasms
(blood, drug therapy, pathology)
- Testosterone
(blood)
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