Apolipoprotein A1 is associated with SYNTAX score in patients with a non-ST segment elevation myocardial infarction.

Abstract

BACKGROUND:

The study was designed to investigate lipid profile and SYNTAX score in patients with non-ST segment elevation myocardial infarction (NSTEMI).

METHODS:

311 patients with NSTEMI were enrolled. The demographic, clinical data, blood samples and SYNTAX score were documented. The Pearson linear correlation was used to detect confounding factors linearly correlated with SYNTAX score. The significantly correlated confounding factors were put into the multiple linear regressions.

RESULTS:

The Pearson linear correlation showed that high-density lipoprotein- cholesterol (HDL-C) and apolipoprotein A1 (ApoA1) were significantly correlated with Syntax Score (r = - 0.119, P = 0.044 and r = - 0.182, P = 0.002, respectively). The multiple linear regressions for Syntax Score were built using HDL-C and ApoA1, respectively. After the adjustment of other significantly correlated confounding factors such as white blood cell count (WBC), myohemoglobin (MB), glutamic-oxalacetic transaminase (AST) and creatinine, the ApoA1 still showed significant association with Syntax Score (β = - 0.151, P = 0.028). The area under curve was (AUC) 0.624 and the optimal cutoff value is 1.07 g/L when using ApoA1 to predict moderate and severe coronary artery lesions. The patients with ApoA1 ≥ 1.07 g/L and < 1.07 g/L have the Syntax Scores of 12.21 ± 11.58 and 16.33 ± 11.53, respectively (P = 0.001).

CONCLUSIONS:

The ApoA1 is the only lipid factor significantly associated with complexity of coronary artery lesion in patients with NSTEMI, the patients with ApoA1 < 1.07 g/L may have more complex coronary artery lesions.

• Authors: Bang-Dang Chen, Xiao-Cui Chen, Yi-Ning Yang, Xiao-Ming Gao, Xiang Ma, Ying Huang, Xiao-Mei Li, Min-Tao Gai, Fen Liu, Shuo Pan, Yi-Tong Ma
• Journal: Lipids in health and disease (Lipids Health Dis) Vol. 18 Issue 1 Pg. 159 (Aug 07 2019) ISSN: 1476-511X [Electronic] England
• PMID: 31391051 (Publication Type: Journal Article, Observational Study)

Chemical References

• APOA1 protein, human
• Apolipoprotein A-I
• Biomarkers
• Cholesterol, HDL
• Myoglobin
• Creatinine
• Aspartate Aminotransferases

Topics

• Adult
• Aged
• Aged, 80 and over
• Apolipoprotein A-I (blood)
• Area Under Curve
• Aspartate Aminotransferases (blood)
• Biomarkers (blood)
• Cholesterol, HDL (blood)
• Creatinine (blood)
• Cross-Sectional Studies
• Female
• Humans
• Leukocyte Count
• Linear Models
• Male
• Middle Aged
• Myoglobin (blood)
• Non-ST Elevated Myocardial Infarction (blood, diagnosis, physiopathology)
• Severity of Illness Index