Abstract |
An example of an unusual cold autoagglutinin is reported. The antibody was monoclonal IgMKappa able to fix complement, and, in the presence of albumin, had both a high titer (greater than 4,096 at 4 degrees C) and a wide thermal range (4-37 degrees C). The patient was closely followed over a 3-year period with no evidence of hemolysis ever documented, despite a persistently positive direct antiglobulin test and the presence of the cold autoagglutinin. In contrast to previous reports regarding cold-agglutinin disease, this case demonstrates that in vivo hemolysis is not always associated with cold autoagglutinins that in vitro show a high thermal range in the presence of albumin.
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Authors | I Sniecinski, K Margolin, I Shulman, L Oien, E Meyer, D R Branch |
Journal | Vox sanguinis
(Vox Sang)
Vol. 55
Issue 1
Pg. 26-9
( 1988)
ISSN: 0042-9007 [Print] England |
PMID | 3138816
(Publication Type: Journal Article)
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Chemical References |
- Agglutinins
- Immunoglobulin kappa-Chains
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Topics |
- Agglutinins
(analysis)
- Anemia, Hemolytic
(blood)
- Cold Temperature
- Coombs Test
- Humans
- Immunoglobulin kappa-Chains
(analysis)
- Male
- Middle Aged
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