Abstract | PURPOSE: To compare the clinical efficacy of high-dose prednisone monotherapy and the combination of hormone and moderate-dose topiramate (TPM) therapy in children with infantile spasms (IS) and late-onset epileptic spasms (ES), and to evaluate whether the addition of TPM would provide more benefits for patients. METHODS: All patients were assigned to receive either high-dose prednisone alone (the maximum doses was 60 mg a day) or high-dose prednisone with TPM (the moderate doses was 5 mg/kg/day). The primary outcome was the proportion of children who achieved cessation of spasms at day-49 or day-56 after initial treatment (the minimum duration of treatment were 49 days). RESULTS: 77 patients were randomly divided into two groups. The control rate of spasms on day-14 in hormone monotherapy was similar to combination therapy (71.8% vs 76.3%, p = 0.796). The cessation of spasms rate of patients on day-49 or day-56 was also similar between the two groups (71.8% vs 65.8%, p = 0.569). After 4 months, the cessation of spasms rate of patients in the group of hormone monotherapy was higher than the group of combination therapy, but there was no significant difference (61.5% vs 50.0%, p = 0.308). CONCLUSION: The efficacy of the combination therapy was not better than that of the monotherapy in achieving spasm freedom at 14-days, 49-days or 56-days and day-120 in the patients. Adding-on moderate-dose TPM did not help more children achieve spasm freedom and provided no benefit for prevention of IS and late-onset ES in short term. Higher-dose regimens of TPM might be more effective.
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Authors | Zhaoshi Yi, Huaping Wu, Xiongying Yu, Jian Zha, Hui Chen, Yong Chen, Jianmin Zhong |
Journal | Seizure
(Seizure)
Vol. 71
Pg. 174-178
(Oct 2019)
ISSN: 1532-2688 [Electronic] England |
PMID | 31382136
(Publication Type: Comparative Study, Journal Article)
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Copyright | Copyright © 2019 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved. |
Chemical References |
- Anticonvulsants
- Glucocorticoids
- Topiramate
- Prednisone
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Topics |
- Age of Onset
- Anticonvulsants
(administration & dosage, pharmacology)
- Child, Preschool
- Drug Therapy, Combination
- Female
- Glucocorticoids
(administration & dosage, pharmacology)
- Humans
- Infant
- Male
- Outcome Assessment, Health Care
- Prednisone
(administration & dosage, pharmacology)
- Spasms, Infantile
(drug therapy)
- Topiramate
(administration & dosage, pharmacology)
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