The relevance of 25-hydroxycalciferol measurements in sera of patients with renal failure.

Abstract

Iliac crest biopsies and serum specimens were obtained from 36 non-dialyzed uraemic patients. The mean serum 25-hydroxycalciferol concentration of the patients was lower than that of normal subjects and a significant correlation was found between 25-hydroxycalciferol values and the severity of osteomalacia. Parathyroid osteopathy was significantly correlated with serum immunoreactive parathyroid hormone but not with serum 25-hydroxycalciferol values. While normal serum 25-hydroxycalciferol concentrations in uraemic patients do not exclude the presence of osteomalacia, a low concentration is virtually diagnostic of this disorder.

• Authors: R S Mason, D Moddel, A McElduff, J H Stewart, J F Mahony, S Posen
• Journal: Australian and New Zealand journal of medicine (Aust N Z J Med) Vol. 9 Issue 3 Pg. 257-60 (Jun 1979) ISSN: 0004-8291 [Print] Australia
• PMID: 313783 (Publication Type: Journal Article)

Chemical References

• Antigens
• Ergocalciferols
• Parathyroid Hormone

Topics

• Antigens
• Ergocalciferols (analogs & derivatives, blood)
• Humans
• Kidney Failure, Chronic (blood, complications)
• Osteomalacia (blood, complications, diagnosis)
• Parathyroid Hormone (blood)