Fenfluramine-induced suppression of food intake and locomotor activity is differentially altered by the selective type A monoamine oxidase inhibitor clorgyline.

Abstract

Administration of fenfluramine to rats produced decreases in 1-h food intake and locomotor activity. Short-term (2-6 days) or long-term (21-25 days) treatment with the monoamine oxidase (MAO) type A inhibiting antidepressant clorgyline potentiated fenfluramine-induced suppression of food intake but did not affect fenfluramine-induced suppression of locomotor activity. Although daily (4 h) food intake was not significantly less in clorgyline-treated animals relative to saline-treated controls, body weight gain was significantly less in clorgyline-treated animals relative to controls. These findings demonstrate a differential effect of clorgyline treatment on fenfluramine-induced suppression of food intake and locomotor activity.

• Authors: C S Aulakh, J L Hill, K M Wozniak, D L Murphy
• Journal: Psychopharmacology (Psychopharmacology (Berl)) Vol. 95 Issue 3 Pg. 313-7 ( 1988) ISSN: 0033-3158 [Print] Germany
• PMID: 3137616 (Publication Type: Journal Article)

Chemical References

• Propylamines
• Fenfluramine
• Clorgyline

Topics

• Animals
• Body Weight (drug effects)
• Clorgyline (pharmacology)
• Drug Interactions
• Eating (drug effects)
• Fenfluramine (pharmacology)
• Male
• Motor Activity (drug effects)
• Propylamines (pharmacology)
• Rats
• Rats, Inbred Strains
• Time Factors