Abstract | RATIONALE:
Vandetanib is effective for treating symptomatic or progressive medullary thyroid cancer (MTC) in patients with unresectable locally advanced or metastatic disease, but its toxicity such as photosensitivity reactions should be considered. It is a rare adverse effect of this drug but might cause severe morbidity and even mortality. PATIENT CONCERNS: A 26-year man with MTC developed phototoxic rashes on the sun-exposed areas of his shin after 15 days from the initiation of vandetanib treatment. Grade II skin toxicity was evaluated based on the Common Terminology Criteria for Adverse Events standard. DIAGNOSES: INTERVENTIONS: OUTCOMES: LESSONS: Close attention should be paid to the adverse effect of vandetanib, phototoxic rash, and patients should be advised on the prevention and treatment measures.
|
Authors | Yue Yin, Xin Ye Qiu, Yan Hua Zhang, Bin Zhang |
Journal | Medicine
(Medicine (Baltimore))
Vol. 98
Issue 31
Pg. e16392
(Aug 2019)
ISSN: 1536-5964 [Electronic] United States |
PMID | 31374006
(Publication Type: Case Reports, Journal Article)
|
Chemical References |
- Antineoplastic Agents
- Piperidines
- Quinazolines
- vandetanib
|
Topics |
- Adult
- Antineoplastic Agents
(adverse effects, therapeutic use)
- Dermatitis, Phototoxic
(etiology)
- Drug-Related Side Effects and Adverse Reactions
- Humans
- Male
- Piperidines
(adverse effects, therapeutic use)
- Quinazolines
(adverse effects, therapeutic use)
- Thyroid Neoplasms
(drug therapy)
|