Abstract |
The phenazine pigments pyocyanin and 1-hydroxyphenazine were resolved by high-pressure liquid chromatography from the sputum sol phase from 9 of 13 patients with cystic fibrosis or bronchiectasis colonized by Pseudomonas aeruginosa. The concentrations measured were each sufficient to inhibit ciliary beating in vitro and contributed a significant proportion of sol phase toxicity for respiratory epithelium.
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Authors | R Wilson, D A Sykes, D Watson, A Rutman, G W Taylor, P J Cole |
Journal | Infection and immunity
(Infect Immun)
Vol. 56
Issue 9
Pg. 2515-7
(Sep 1988)
ISSN: 0019-9567 [Print] United States |
PMID | 3137173
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Phenazines
- Pigments, Biological
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Topics |
- Cilia
(drug effects, microbiology)
- Epithelium
(drug effects, microbiology)
- Humans
- Nasal Mucosa
(drug effects, microbiology)
- Phenazines
(analysis, toxicity)
- Pigments, Biological
(analysis, toxicity)
- Pseudomonas Infections
(microbiology)
- Pseudomonas aeruginosa
(analysis)
- Sputum
(analysis, microbiology)
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