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Measurement of Pseudomonas aeruginosa phenazine pigments in sputum and assessment of their contribution to sputum sol toxicity for respiratory epithelium.

Abstract
The phenazine pigments pyocyanin and 1-hydroxyphenazine were resolved by high-pressure liquid chromatography from the sputum sol phase from 9 of 13 patients with cystic fibrosis or bronchiectasis colonized by Pseudomonas aeruginosa. The concentrations measured were each sufficient to inhibit ciliary beating in vitro and contributed a significant proportion of sol phase toxicity for respiratory epithelium.
AuthorsR Wilson, D A Sykes, D Watson, A Rutman, G W Taylor, P J Cole
JournalInfection and immunity (Infect Immun) Vol. 56 Issue 9 Pg. 2515-7 (Sep 1988) ISSN: 0019-9567 [Print] United States
PMID3137173 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Phenazines
  • Pigments, Biological
Topics
  • Cilia (drug effects, microbiology)
  • Epithelium (drug effects, microbiology)
  • Humans
  • Nasal Mucosa (drug effects, microbiology)
  • Phenazines (analysis, toxicity)
  • Pigments, Biological (analysis, toxicity)
  • Pseudomonas Infections (microbiology)
  • Pseudomonas aeruginosa (analysis)
  • Sputum (analysis, microbiology)

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