Abstract | OBJECTIVE: METHODS: The Intensive Statin Treatment in Acute Ischaemic Stroke Patients with Intracranial Atherosclerosis - High-Resolution Magnetic Resonance Imaging (STAMINA-MRI) Trial is a single-arm, prospective, observational study monitoring imaging and clinical outcomes of high-dose statin treatment among statin-naive patients with acute ischaemic stroke caused by symptomatic intracranial atherosclerosis. The primary outcome was the change in vascular remodelling and plaque characteristics before and after 6 months (median: 179 days, IQR 163-189 days) of statin treatment measured by high-resolution MRI (HR-MRI). RESULTS: A total of 77 patients (mean age: 62.6±13.7 years, 61.0% women) were included in this study. Low-density lipoprotein cholesterol ( LDL-C) levels (mg/dL) at initial and follow-up assessments were 125.81±35.69 and 60.95±19.28, respectively. Overall, statin treatment significantly decreased enhancement of plaque volume (mm3, 32.07±39.15 vs 17.06±34.53, p=0.013), the wall area index (7.50±4.28 vs 5.86±4.05, p=0.016) and stenosis degree (%, 76.47±20.23 vs 64.05±21.29, p<0.001), but not the remodelling index (p=0.195). However, 35% patients showed no change or increased enhancement volume and stenosis degree after statin treatment. Higher reduction of LDL-C and longer duration of statin treatment were associated with decreased enhancement volume after statin treatment. CONCLUSIONS: TRIAL REGISTRATION NUMBER: ClinicalTrials.gov NCT02458755.
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Authors | Jong-Won Chung, Jihoon Cha, Mi Ji Lee, In-Wu Yu, Moo-Seok Park, Woo-Keun Seo, Sung Tae Kim, Oh Young Bang |
Journal | Journal of neurology, neurosurgery, and psychiatry
(J Neurol Neurosurg Psychiatry)
Vol. 91
Issue 2
Pg. 204-211
(02 2020)
ISSN: 1468-330X [Electronic] England |
PMID | 31371644
(Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions. Published by BMJ. |
Chemical References |
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
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Topics |
- Brain
(diagnostic imaging)
- Female
- Humans
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
(administration & dosage, therapeutic use)
- Intracranial Arteriosclerosis
(complications, diagnostic imaging, drug therapy)
- Magnetic Resonance Imaging
- Male
- Middle Aged
- Neuroimaging
- Stroke
(diagnostic imaging, drug therapy, etiology)
- Treatment Outcome
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