Effect of cyclooxygenase-2 inhibitors at therapeutic doses on body temperature during anesthesia in healthy dogs administered with amino acids.

Abstract

In healthy dogs, amino acid infusion significantly attenuates the decrease in body temperature during anesthesia by facilitating insulin secretion, suggesting that such an increase in insulin secretion is related to increased heat production. In dogs, selective cyclooxygenase-2 (COX-2) inhibitors, which are used for pain relief in veterinary medicine, possess anti-pyretic action. And, in mice and humans, selective COX-2 inhibitors increase insulin secretion and sensitivity. Therefore, treatment with COX-2 inhibitors may negate or accelerate the attenuating effect on decreased body temperature during anesthesia by amino acid infusion. In the present study, influences on insulin secretion and body temperature by treatment with meloxicam or robenacoxib at therapeutic dose were evaluated in healthy dogs. Treatment with meloxicam or robenacoxib did not affect insulin secretion in the unanesthetized and anesthetized dogs, and did not affect body temperature and heart rate under the anesthetized condition with amino acid infusion. In conclusion, COX-2 inhibitors at therapeutic doses did not affect body temperature during anesthesia in dogs administered amino acids.

• Authors: Satoshi Takashima, Shin-Ichi Takitani, Maasa Kitamura, Naohito Nishii, Hitoshi Kitagawa, Sanae Shibata
• Journal: The Journal of veterinary medical science (J Vet Med Sci) Vol. 81 Issue 9 Pg. 1379-1384 (Oct 10 2019) ISSN: 1347-7439 [Electronic] Japan
• PMID: 31366852 (Publication Type: Journal Article)

Chemical References

• Amino Acids
• Cyclooxygenase 2 Inhibitors
• Phenylacetates
• Diphenylamine
• Meloxicam
• robenacoxib

Topics

• Amino Acids (administration & dosage)
• Anesthesia (adverse effects, veterinary)
• Animals
• Body Temperature (drug effects)
• Cyclooxygenase 2 Inhibitors (administration & dosage, pharmacology)
• Diphenylamine (administration & dosage, analogs & derivatives, pharmacology)
• Dogs
• Female
• Glucose Tolerance Test (veterinary)
• Heart Rate (drug effects)
• Infusions, Intravenous (veterinary)
• Insulin Secretion (drug effects)
• Male
• Meloxicam (administration & dosage, pharmacology)
• Phenylacetates (administration & dosage, pharmacology)