Low IRBIT Levels Are Associated With Chemo-resistance in Gastric Cancer Patients.

Abstract

BACKGROUND/AIM:

We investigated whether the expression of inositol 1, 4, 5-trisphosphate receptor-binding protein released with inositol 1, 4, 5-trisphosphate (IRBIT) in clinical gastric cancer (GC) patients could predict the therapeutic response to postoperative adjuvant chemotherapy.

MATERIALS AND METHODS:

Immunohistochemistry was used to investigate IRBIT expression in 115 GC patients. To clarify whether IRBIT had a relationship with the therapeutic effects of chemotherapy, we compared two groups - 62 patients treated with postoperative adjuvant chemotherapy and 53 patients treated with postoperative adjuvant chemotherapy.

RESULTS:

Regarding the postoperative adjuvant chemotherapy-free group, we did not find any statistically significant correlation between clinicopathological features and recurrence regardless of the expression of IRBIT. In contrast, in the group receiving postoperative adjuvant chemotherapy, a significant association was found between IRBIT expression and both overall and disease-free survival.

CONCLUSION:

IRBIT may be used as a useful predictive marker for chemotherapy.

• Authors: Nobuhiro Nakazawa, Kyoichi Ogata, Takehiko Yokobori, Munenori Ide, Seded Baatar, Yasunari Ubukata, Akiharu Kimura, Norimichi Kogure, Makoto Sohda, Hiroyuki Kuwano, Hiroshi Saeki, Ken Shirabe
• Journal: Anticancer research (Anticancer Res) Vol. 39 Issue 8 Pg. 4111-4116 (Aug 2019) ISSN: 1791-7530 [Electronic] Greece
• PMID: 31366495 (Publication Type: Journal Article)
• Copyright: Copyright© 2019, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

Chemical References

• Biomarkers, Tumor
• CLECL1 protein, human
• Lectins, C-Type
• Membrane Proteins

Topics

• Aged
• Biomarkers, Tumor (genetics)
• Chemotherapy, Adjuvant (adverse effects)
• Disease-Free Survival
• Female
• Gene Expression Regulation, Neoplastic (drug effects)
• Humans
• Lectins, C-Type (genetics)
• Male
• Membrane Proteins (genetics)
• Middle Aged
• Neoplasm Recurrence, Local (drug therapy, genetics, pathology)
• Phosphorylation (drug effects)
• Protein Binding (drug effects)
• Stomach Neoplasms (drug therapy, genetics, pathology)