Long-term safety and efficacy comparison of immediate-release and sustained-release oral verapamil in systemic hypertension.

The long-term safety and efficacy of twice-daily sustained-release verapamil were assessed compared to thrice-daily immediate-release verapamil in 25 patients with mild to moderate systemic hypertension. Patients were monitored on immediate-release verapamil (480 mg/day) for 6 months and were then placed on twice-daily sustained-release verapamil for an additional 6 months. Immediate-release verapamil, with and without a diuretic, successfully controlled standing and sitting systolic and diastolic blood pressures (p less than 0.001) compared to pretreatment baseline values. The effects of verapamil on blood pressure were sustained for an additional 6 months when the sustained-release formulation was utilized. Both formulations were well tolerated, with no significant effects on heart rate. In conclusion, verapamil, in both the immediate- and sustained-release formulations, is equally effective in lowering blood pressure for up to 1 year.
AuthorsW H Frishman, G Eisen, S Charlap, J A Strom
JournalJournal of clinical hypertension (J Clin Hypertens) Vol. 3 Issue 4 Pg. 605-9 (Dec 1987) ISSN: 0748-450X [Print] UNITED STATES
PMID3134517 (Publication Type: Clinical Trial, Comparative Study, Journal Article)
Chemical References
  • Delayed-Action Preparations
  • Verapamil
  • Administration, Oral
  • Adult
  • Aged
  • Blood Pressure (drug effects)
  • Clinical Trials as Topic
  • Delayed-Action Preparations
  • Female
  • Heart Rate (drug effects)
  • Humans
  • Hypertension (drug therapy)
  • Long-Term Care
  • Male
  • Middle Aged
  • Verapamil (administration & dosage, adverse effects)

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