Abstract |
Methicillin resistant Staphylococcus aureus strains (MRSA) have become increasingly prevalent as pathogenic organisms, especially in burn wounds, with an associated mortality of 20-40% among those clinically infected. Mupirocin ointment, a new topical antibiotic, has proved in vitro and in vivo to be highly effective in the treatment of MRSA infections. A modified Walker burn wound model was used to define the rate of trans-eschar penetration, biodynamic availability and bactericidal efficacy of 2% mupirocin ointment in established MRSA burn wound infection. In-vitro penetration trials confirmed the effective diffusion of mupirocin through 1.5 mm eschar within 2 h. A single topical application of mupirocin resulted in a 98.3% (5.67 x 10(8) cfu/g of tissue--1.0 x 10(7) cfu/g of tissue) reduction in intra-eschar viable organisms within 36 h post application. A second topical application of mupirocin at 24 h resulted in a total reduction of 99.6% in viable intra-eschar organisms (1.85 x 10(8) cfu/gram of tissue--6.76 x 10(5) cfu/g of tissue). It is concluded that mupirocin is highly effective in controlling MRSA burn wound infection and should be applied topically every 24 h.
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Authors | H Rode, P M de Wet, A J Millar, S Cywes |
Journal | The Journal of antimicrobial chemotherapy
(J Antimicrob Chemother)
Vol. 21
Issue 5
Pg. 589-95
(May 1988)
ISSN: 0305-7453 [Print] England |
PMID | 3134320
(Publication Type: Journal Article)
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Chemical References |
- Anti-Bacterial Agents
- Fatty Acids
- Ointments
- Mupirocin
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Topics |
- Animals
- Anti-Bacterial Agents
(administration & dosage, pharmacokinetics, pharmacology)
- Biological Availability
- Burns
(complications, drug therapy)
- Drug Resistance, Microbial
- Fatty Acids
(administration & dosage, pharmacokinetics, pharmacology)
- Mupirocin
- Ointments
- Rats
- Staphylococcal Skin Infections
(drug therapy)
- Staphylococcus aureus
(drug effects)
- Wound Infection
(drug therapy)
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