Graft Survival After Penetrating and Endothelial Keratoplasty in Iridocorneal Endothelial Syndrome.

Abstract

PURPOSE:

To compare the survival of a first penetrating keratoplasty (PK) or endothelial keratoplasty (EK) for iridocorneal endothelial (ICE) syndrome with transplant survival in Fuchs endothelial dystrophy (FED) and pseudophakic bullous keratopathy (PBK).

METHODS:

We compared graft survival of PK and EK for ICE syndrome for 2 time periods. We then compared graft survival in ICE syndrome with graft survival in FED and PBK. Kaplan-Meier estimates of graft survival up to 5 years posttransplant were calculated with 95% confidence intervals (CI), whereas comparisons between the groups were performed using the log-rank test.

RESULTS:

We included 86 first transplants for ICE syndrome. There was no difference in graft survival between the 58 PKs and the 28 EKs for up to 5 years after surgery (P = 0.717). For the period from 2009 to 2017, the 5-year graft survival rates for ICE syndrome were 64.3% (CI, 21.8%-88.0%) for the 16 PKs and 66.8% (CI, 41.8%-83.0%) for the 26 EKs (P = 0.469). Between 2009 and 2017, the 5-year survival rate for 42 grafts with ICE syndrome was 62.7% (CI, 39.6%-79.0%), which was lower than 75.9% (CI, 74.2%-77.4%) in 7058 transplants for FED but higher than 55.1% (CI, 52.0%-58.0%) in 3320 transplants for PBK, although the numbers of ICE transplants are too small to tell whether this difference was by chance.

CONCLUSIONS:

The results indicate no difference in graft survival between PK and EK for ICE syndrome. Graft survival in ICE syndrome is intermediate between that of FED and PBK.

• Authors: Michael Rotenberg, Lewis Downward, Elinor Curnow, Daniel F Larkin, Stephen J Tuft, National Health Service Blood and Ocular Tissue Advisory Group and Contributing Ophthalmologists (OTAG Study 27)
• Journal: Cornea (Cornea) Vol. 39 Issue 1 Pg. 18-22 (Jan 2020) ISSN: 1536-4798 [Electronic] United States
• PMID: 31335531 (Publication Type: Comparative Study, Journal Article)

Topics

• Descemet Stripping Endothelial Keratoplasty (methods)
• Endothelium, Corneal (transplantation)
• Female
• Follow-Up Studies
• Fuchs' Endothelial Dystrophy (diagnosis, surgery)
• Graft Rejection (epidemiology, prevention & control)
• Graft Survival
• Humans
• Incidence
• Iridocorneal Endothelial Syndrome (diagnosis, surgery)
• Keratoplasty, Penetrating (methods)
• Male
• Middle Aged
• Registries
• Retrospective Studies
• Risk Factors
• Time Factors
• Treatment Outcome
• United Kingdom (epidemiology)
• Visual Acuity