Distinct HR expression patterns significantly affect the clinical behavior of metastatic HER2+ breast cancer and degree of benefit from novel anti-HER2 agents in the real world setting.
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| Abstract |
We analyzed data from 738 HER2-positive metastatic breast cancer (mbc) patients treated with pertuzumab-based regimens and/or T-DM1 at 45 Italian centers. Outcomes were explored in relation to tumor subtype assessed by immunohistochemistry (IHC). The median progression-free survival at first-line (mPFS1) was 12 months. Pertuzumab as first-line conferred longer mPFS1 compared to other first-line treatments (16 vs. 9 months, p = 0.0001), regardless of IHC subtype. Median PFS in second-line (mPFS2) was 7 months, with no difference by IHC subtype, but it was more favorable with T-DM1 compared to other agents (7 vs. 6 months, p = 0.03). There was no PFS2 gain in patients with tumors expressing both hormonal receptors (HRs; p = 0.17), while a trend emerged for tumors with one HR (p = 0.05). Conversely, PFS2 gain was significant in HRs-negative tumors (p = 0.04). Median overall survival (mOS) was 74 months, with no significant differences by IHC subtypes. Survival rates at 2 and 3 years in patients treated with T-DM1 in second-line after pertuzumab were significantly lower compared to pertuzumab-naïve patients (p = 0.01). When analyzed by IHC subtype, the outcome was confirmed if both HRs or no HRs were expressed (p = 0.02 and p = 0.006, respectively). Our results confirm that HRs expression impacts the clinical behavior and novel treatment-related outcomes of HER2-positive tumors when treatment sequences are considered. Moreover, multivariate analysis showed that HRs expression had no effect on PFS and OS. Further studies are warranted to confirm our findings and clarify the interplay between HER2 and estrogen receptor pathways in HER2-positive (mbc) patients.
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| Authors | Laura Pizzuti, Eriseld Krasniqi, Giacomo Barchiesi, Marina Della Giulia, Fiorentino Izzo, Giuseppe Sanguineti, Paolo Marchetti, Marco Mazzotta, Raffaele Giusti, Andrea Botticelli, Teresa Gamucci, Clara Natoli, Antonino Grassadonia, Nicola Tinari, Laura Iezzi, Silverio Tomao, Federica Tomao, Giuseppe Tonini, Daniele Santini, Antonio Astone, Andrea Michelotti, Claudia De Angelis, Lucia Mentuccia, Angela Vaccaro, Emanuela Magnolfi, Alain Gelibter, Valentina Magri, Enrico Cortesi, Loretta D'Onofrio, Alessandra Cassano, Ernesto Rossi, Marina Cazzaniga, Luca Moscetti, Claudia Omarini, Federico Piacentini, Maria A Fabbri, Angelo F Scinto, Domenico Corsi, Luisa Carbognin, Emilio Bria, Nicla La Verde, Riccardo Samaritani, Carlo Garufi, Sandro Barni, Rosanna Mirabelli, Roberta Sarmiento, Enzo M Veltri, Giuliana D'Auria, Ida Paris, Francesco Giotta, Vito Lorusso, Franca Cardillo, Elisabetta Landucci, Maria Mauri, Corrado Ficorella, Mario Roselli, Vincenzo Adamo, Giuseppina R R Ricciardi, Antonio Russo, Rossana Berardi, Mirco Pistelli, Elena Fiorio, Katia Cannita, Valentina Sini, Nicola D'Ostilio, Jennifer Foglietta, Filippo Greco, Claudio Zamagni, Ornella Garrone, Barbara Di Cocco, Editta Baldini, Lorenzo Livi, Isacco Desideri, Icro Meattini, Giuseppina Sarobba, Pietro Del Medico, Michele De Tursi, Daniele Generali, Ruggero De Maria, Emanuela Risi, Gennaro Ciliberto, Isabella Sperduti, Alice Villa, Maddalena Barba, Angelo Di Leo, Patrizia Vici |
| Journal | International journal of cancer (Int J Cancer) Vol. 146 Issue 7 Pg. 1917-1929 (04 01 2020) ISSN: 1097-0215 [Electronic] United States |
| PMID | 31330065 (Publication Type: Journal Article) |
| Copyright | © 2019 The Authors. International Journal of Cancer published by John Wiley & Sons Ltd on behalf of UICC. |
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