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Evaluation of roxithromycin (RU-965) versus cephradine in pneumococcal pneumonia.

Abstract
One hundred and sixty black South African gold miners with acute pneumococcal pneumonia were enrolled in a prospective randomized double-blind trial comparing roxithromycin (150 mg 2 X day) with cephradine (1.0 g 2 X day). Ninety patients with pneumonia caused by Streptococcus pneumoniae were treated for 5-10 days. Forty-three of 46 (93.4%) of the roxithromycin and all 44 (100%) of the cephradine treated groups had satisfactory clinical responses. In eight of the 46 (17%) roxithromycin treated patients and 10 of the 44 (23%) cephradine treated patients, Streptococcus pneumoniae was not eradicated from sputum cultures by the tenth day. Side effects in 18 patients (20%) were mild and were usually manifested by elevation of the transaminases; these were more common in the cephradine group (12) than in the roxithromycin group (5). Roxithromycin appears to be a safe and effective oral antibiotic for treatment of patients with mild to moderate pneumococcal pneumonia.
AuthorsB J Zeluff, P Lowe, H J Koornhof, L O Gentry
JournalEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology (Eur J Clin Microbiol Infect Dis) Vol. 7 Issue 1 Pg. 69-71 (Feb 1988) ISSN: 0934-9723 [Print] Germany
PMID3132383 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
Chemical References
  • Anti-Bacterial Agents
  • Cephalosporins
  • Leucomycins
  • Cephradine
Topics
  • Adult
  • Anti-Bacterial Agents (therapeutic use)
  • Black People
  • Cephalosporins (therapeutic use)
  • Cephradine (therapeutic use)
  • Clinical Trials as Topic
  • Double-Blind Method
  • Humans
  • Leucomycins (therapeutic use)
  • Male
  • Middle Aged
  • Occupational Diseases (drug therapy)
  • Pneumonia, Pneumococcal (drug therapy)
  • Prospective Studies
  • Random Allocation
  • South Africa
  • Sputum (microbiology)

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