Abstract |
Effects of thyrotropin-releasing hormone (TRH) analogs were compared in rats to evaluate the structure-activity relationships of such compounds in the treatment of traumatic spinal cord injury. CG3703, a TRH analog having a modified amino-terminus, significantly improved motor recovery and somatosensory-evoked responses after trauma; in contrast, RX77368, which has a modified carboxy-terminus, was without effect, even at doses up to 10 mg/kg. These findings confirm and extend findings in cats, using other TRH analogs in a different model of spinal trauma. Together, data from rat and cat studies are consistent with the hypothesis that the integrity of the C-terminal amino acid may be critical for the beneficial effects of treatment with TRH and TRH analogs in experimental spinal injury, and suggest that a variety of other TRH analogs having substitutions of the pyroglutamyl or histidyl moieties of the tripeptide may also prove to be effective in the treatment of such injury.
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Authors | A I Faden, I Sacksen, L J Noble |
Journal | Brain research
(Brain Res)
Vol. 448
Issue 2
Pg. 287-93
(May 17 1988)
ISSN: 0006-8993 [Print] Netherlands |
PMID | 3132308
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- montirelin
- Thyrotropin-Releasing Hormone
- L-pyroglutamyl-L-histidyl-3,3-dimethylprolinamide
- Pyrrolidonecarboxylic Acid
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Topics |
- Animals
- Evoked Potentials, Somatosensory
- Molecular Conformation
- Pyrrolidonecarboxylic Acid
(analogs & derivatives)
- Rats
- Spinal Cord Injuries
(drug therapy, pathology, physiopathology)
- Thyrotropin-Releasing Hormone
(analogs & derivatives, therapeutic use)
- Time Factors
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