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Construction of recombinant capripoxviruses as vaccine vectors for delivering foreign antigens: Methodology and application.

Abstract
Goatpox (GTP), sheeppox (SPP) and lumpy skin disease (LSD) are three severe diseases of goat, sheep and cattle. Their typical clinical symptoms are characterized by vesicles, papules, nodules, pustules and scabs on animal skins. The GTP, SPP and LSD are caused by goatpox virus (GTPV), sheeppox virus (SPPV) and lumpy skin disease virus (LSDV), respectively, all of which belong to the genus Capripoxvirus in the family Poxviridae. Several capripoxvirus (CaPV) isolates have been virulently attenuated through serial passaging in vitro for production of live vaccines. CaPV-based vector systems have been broadly used to construct recombinant vaccines for delivering foreign antigens, many of which have been demonstrated to induce effective immune protections. Homologous recombination is the most commonly used method for constructing recombinant CaPVs. Here, we described a methodology for generation of recombinant CaPVs by the homologous recombination, and further reviewed CaPV-vectored vaccines for delivering foreign antigens.
AuthorsFuxiao Liu, Hongliang Zhang, Wenhua Liu
JournalComparative immunology, microbiology and infectious diseases (Comp Immunol Microbiol Infect Dis) Vol. 65 Pg. 181-188 (Aug 2019) ISSN: 1878-1667 [Electronic] England
PMID31300111 (Publication Type: Journal Article, Review)
CopyrightCopyright © 2019 Elsevier Ltd. All rights reserved.
Chemical References
  • DNA, Viral
  • Vaccines, Attenuated
  • Vaccines, Synthetic
  • Viral Vaccines
Topics
  • Animals
  • Capripoxvirus (genetics)
  • Clinical Trials, Veterinary as Topic
  • DNA, Viral (genetics)
  • Genetic Engineering
  • Genetic Vectors
  • Goat Diseases (prevention & control, virology)
  • Goats
  • Homologous Recombination
  • Poxviridae Infections (prevention & control, veterinary)
  • Sheep
  • Sheep Diseases (prevention & control, virology)
  • Vaccines, Attenuated (immunology)
  • Vaccines, Synthetic (immunology)
  • Viral Vaccines (genetics, immunology)

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