Generalized peliosis hepatis and cirrhosis after long-term use of oral contraceptives.

Abstract

Peliosis hepatis, a condition characterized by the presence of blood-filled lacunar spaces in the liver, has been described primarily in patients on androgenic steroid medication and patients with tuberculosis. It has never been reported as a complication of the use of oral contraceptives, except in association with and localized in contraceptive-induced hepatic tumors. The present report concerns a 43-yr-old woman with generalized peliosis hepatis that developed during long-term use of oral contraceptives. Extensive examination did not reveal a hepatic tumor. Liver cirrhosis and portal hypertension developed, although the oral contraceptives had been withdrawn. She finally underwent successfully an orthotopic liver transplantation.

• Authors: K J van Erpecum, A R Janssens, J Kreuning, D J Ruiter, H M Kroon, A J Grond
• Journal: The American journal of gastroenterology (Am J Gastroenterol) Vol. 83 Issue 5 Pg. 572-5 (May 1988) ISSN: 0002-9270 [Print] United States
• PMID: 3129933 (Publication Type: Case Reports, Journal Article)

Chemical References

• Contraceptives, Oral, Synthetic
• Norgestrel
• Ethinyl Estradiol
• Levonorgestrel
• Lynestrenol

Topics

• Adult
• Chemical and Drug Induced Liver Injury
• Contraceptives, Oral, Synthetic (adverse effects)
• Ethinyl Estradiol (adverse effects)
• Female
• Humans
• Levonorgestrel
• Liver (diagnostic imaging, pathology)
• Liver Cirrhosis (chemically induced, diagnostic imaging, pathology)
• Lynestrenol (adverse effects)
• Norgestrel (adverse effects)
• Peliosis Hepatis (chemically induced, diagnostic imaging, pathology)
• Radiography
• Time Factors