Enoxacin: in-vitro and animal evaluation as a parenteral and oral agent against hospital bacterial isolates.

Abstract

Enoxacin was evaluated in in-vitro tests and in studies of effectiveness and blood concentrations in the mouse. Enoxacin was active against both susceptible and multiresistant hospital isolates of Enterobacteriaceae, Pseudomonas aeruginosa, Haemophilus influenzae, Neisseria gonorrhoeae and staphylococci. Less susceptible were streptococci and anaerobes. Of nine quinolones tested, only norfloxacin was equivalent in vitro. The MBCs of enoxacin were one- to twofold greater than the MICs, and enoxacin was rapidly bactericidal. No single-step resistant mutants could be detected at 10 mg/l against large inocula and six to 11 steps were required for selection of resistant clones. In systemic mouse infections, enoxacin was effective in a single oral or subcutaneous dose against one strain each of Enterobacter cloacae, Escherichia coli, Klebsiella pneumoniae, Providencia rettgeri and Ps. aeruginosa, and two Staphylococcus aureus strains. Single oral and subcutaneous enoxacin doses (50 mg/kg) gave peak mouse blood levels of 4.9 and 9.5 mg/l and an elimination half-life of 1.8 h.

• Authors: C L Heifetz, P A Bien, M A Cohen, M E Dombrowski, T J Griffin, T E Malta, J C Sesnie, M A Shapiro, S A Wold
• Journal: The Journal of antimicrobial chemotherapy (J Antimicrob Chemother) Vol. 21 Suppl B Pg. 29-42 (Feb 1988) ISSN: 0305-7453 [Print] England
• PMID: 3129392 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Anti-Bacterial Agents
• Naphthyridines
• Enoxacin

Topics

• Animals
• Anti-Bacterial Agents (pharmacokinetics, pharmacology, therapeutic use)
• Drug Evaluation, Preclinical
• Enoxacin
• Enterobacteriaceae (drug effects)
• Enterobacteriaceae Infections (drug therapy)
• Female
• Mice
• Naphthyridines (pharmacokinetics, pharmacology, therapeutic use)
• Pseudomonas Infections (drug therapy)
• Pseudomonas aeruginosa (drug effects)
• Staphylococcal Infections (drug therapy)
• Staphylococcus (drug effects)
• Streptococcus (drug effects)