Abstract |
To determine whether clomiphene citrate (CC) improves fertility in oligospermic men, 23 men with sperm concentrations between 0.5 and 20 million sperm per milliliter; normal serum gonadotropins and testosterone; and a presumptively fertile partner were enrolled in the study. After a 3-month control period, patients were randomly prescribed CC, 25 mg/day; or placebo, 1 tablet/day, for 12 months. The pregnancy rates for the CC group and the placebo group were 9.09% and 44.44%, respectively (not significant). During the treatment phase, the CC group had significantly higher levels of luteinizing hormone (LH) serum, follicle-stimulating hormone (FSH), testosterone (T), and estradiol than the placebo group. CC treatment also resulted in greater LH, FSH, and T responses to gonadotropin-releasing hormone ( GnRH). There were no differences between the placebo and CC groups for the sperm penetration assay or semen parameters. The authors conclude that CC is not a useful drug in the treatment of male infertility.
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Authors | R Z Sokol, B S Steiner, M Bustillo, G Petersen, R S Swerdloff |
Journal | Fertility and sterility
(Fertil Steril)
Vol. 49
Issue 5
Pg. 865-70
(May 1988)
ISSN: 0015-0282 [Print] United States |
PMID | 3129318
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Clomiphene
- Gonadotropin-Releasing Hormone
- Testosterone
- Estradiol
- Luteinizing Hormone
- Follicle Stimulating Hormone
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Topics |
- Clomiphene
(therapeutic use)
- Estradiol
(blood)
- Follicle Stimulating Hormone
(blood)
- Gonadotropin-Releasing Hormone
- Humans
- Infertility, Male
(drug therapy)
- Luteinizing Hormone
(blood)
- Male
- Semen
(analysis)
- Sperm Count
- Testosterone
(blood)
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