Abstract |
Fourteen patients with previous optic neuritis (ON) in childhood were examined by magnetic resonance (MR) imaging from two months to 14 years after the onset of symptoms. Five patients had a single monosymptomatic course of ON but 7 developed multiple sclerosis (MS); 2 had another demyelinating disease. Eight patients had high signal intensity areas in the T2 weighted images compatible with MS plaques in MR scan; 2 with monosymptomatic ON, 5 with MS and one with another demyelinating disease. The plaques were periventricular or in the optic radiation. The plaques could already be seen during the first symptoms of ON. All 7 MS patients had abnormal visual evoked response, 3/4 abnormal somatosensory evoked response and 5/6 intrathecal immunoglobulin production, when examined at onset of optic neuritis or at follow-up. All patients except one, with lesions in MR, had either oligoclonal CSF antibodies or Dr2 HLA antigen. We suggest that MR is a very sensitive test showing MR abnormalities in children with ON. It is an important tool in the early assessment of MS.
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Authors | R Riikonen, L Ketonen, J Sipponen |
Journal | Acta neurologica Scandinavica
(Acta Neurol Scand)
Vol. 77
Issue 1
Pg. 44-9
(Jan 1988)
ISSN: 0001-6314 [Print] Denmark |
PMID | 3128051
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- HLA Antigens
- Immunoglobulin gamma-Chains
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Topics |
- Adolescent
- Brain
(pathology, physiopathology)
- Child
- Child, Preschool
- Demyelinating Diseases
(etiology, immunology)
- Evoked Potentials
- Follow-Up Studies
- HLA Antigens
(cerebrospinal fluid)
- Humans
- Immunoglobulin gamma-Chains
(cerebrospinal fluid)
- Magnetic Resonance Imaging
- Multiple Sclerosis
(etiology, immunology)
- Optic Neuritis
(cerebrospinal fluid, diagnosis, physiopathology)
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