Interaction between mitochondrial NADH dehydrogenase subunit-2 5178 C > A and clinical risk factors on the susceptibility of essential hypertension in Chinese population.

Abstract

BACKGROUND:

The mitochondrial genotype 5178 cytosine/adenine (5178 C > A) within the NADH dehydrogenase subunit-2 gene (ND2) was proved to associate with longevity and predispose resistance to adult-onset diseases. This study aimed to confirm the interactive effects between ND 25178 C > A and clinical risk factors on the susceptibility of essential hypertension in Chinese general population.

MATERIALS AND METHODS:

The relationship between the ND2 5178 C > A variation and the risk of hypertension was investigated in 817 hypertensives and 821 matched normotensives. The interactive effects between ND2 5178 C > A and clinical risk factors were evaluated.

RESULTS:

The ND2 5178 A allele was more frequent in normotensives than in hypertensives (32.64% vs. 24.24%; adjusted OR: 0.62, 95% CI: 0.49-0.79, P = 1.3 × 10- 4). After stratification, the significant association between ND2 5178 C > A and hypertension was found only in current smokers (OR: 0.44, 95% CI: 0.31-0.62), but not in non-current smokers (p <  0.01 for interaction). Smoking status (OR: 1.51, 95% CI: 1.11-2.06) and high triglycerides (OR: 1.57, 95% CI: 1.10-2.24) were found independently associated with hypertension only in carriers of 5178 C allele but not in carriers of 5178 A allele.

CONCLUSIONS:

In conclusion, ND2 5178 A allele could confer a lower risk for essential hypertension in Chinese by the interaction with smoking status. The higher risk of hypertension imposed by smoking and high TG may be altered by ND2 5178 A allele.

• Authors: Xi Chen, Xiang-Yu He, Chao Zhu, Yusong Zhang, Zongbin Li, Yuqi Liu, Yuxiao Zhang, Tong Yin, Yang Li
• Journal: BMC medical genetics (BMC Med Genet) Vol. 20 Issue 1 Pg. 121 (07 05 2019) ISSN: 1471-2350 [Electronic] England
• PMID: 31277597 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• NADH Dehydrogenase
• NADH dehydrogenase subunit 2, human

Topics

• Adult
• Alleles
• Asian People (genetics)
• Blood Pressure
• Essential Hypertension (genetics)
• Female
• Genetic Association Studies
• Genetic Predisposition to Disease (genetics)
• Genetic Variation
• Genotype
• Humans
• Longevity (genetics)
• Male
• Middle Aged
• Mitochondria (genetics)
• NADH Dehydrogenase (genetics)
• Odds Ratio
• Risk Factors
• Smoking (adverse effects)