[Euglycemic Diabetic Ketoacidosis Caused by a Sodium-glucose Co-transporter (SGLT) 2 Inhibitor after Coronary Artery Bypass Grafting].

Abstract

A 65-year-old woman with type Ⅱ diabetes and unstable angina presented with chest pain due to in-stent restenosis. Her regular medication comprised an sodium-glucose co-transporter( SGLT) 2 inhibitor. Because of unstable hemodynamic status, semi-emergency coronary artery bypass grafting (CABG) was performed. Postoperatively, the cardiac and hemodynamic status stabilized, but there was progression of metabolic acidosis. Based on the presence of massive urinary ketone bodies without hyper glycosuria, the patient was diagnosed with euglycemic diabetic ketoacidosis( DKA) caused by an SGLT2 inhibitor. Ketoacidosis without elevated blood glucose( i.e., euglycemic DKA) has been reported to be associated with intake of an SGLT2 inhibitor, which promoted glucose excretion in the urine. Our patient developed euglycemic DKA due to the progression of myocardial ischemia and surgical stress. Guidelines in other countries have stipulated that SGLT2 inhibitor should be stopped 24 hours preoperatively. In our case, euglycemic DKA occurred even when the SGLT2 inhibitor was stopped for more than 24 hours preoperatively. Further studies on the withdrawal of an SGLT2 inhibitor in the appropriate perioperative period are required.

• Authors: Yuika Kameda, Masanori Kato, Bon Inoue, Shintaro Yamazaki, Naohiko Sahara, Tomoyuki Aoki, Yoshinori Nagashima, Naohiko Nemoto, Hitoshi Anzai, Wataru Araki, Nobuyuki Kobayashi
• Journal: Kyobu geka. The Japanese journal of thoracic surgery (Kyobu Geka) Vol. 72 Issue 5 Pg. 354-357 (May 2019) ISSN: 0021-5252 [Print] Japan
• PMID: 31268032 (Publication Type: Case Reports, Journal Article)

Chemical References

• Sodium-Glucose Transporter 2 Inhibitors
• Sodium
• Glucose

Topics

• Aged
• Coronary Artery Bypass
• Diabetes Mellitus, Type 2
• Diabetic Ketoacidosis
• Female
• Glucose
• Humans
• Sodium
• Sodium-Glucose Transporter 2 Inhibitors