[Behavior of LH, FSH, total testosterone, free testosterone and SHBG serum levels in the therapy of prostatic cancer with Turisteron (ethinyl estradiol sulfonate)].

Abstract

45 patients with prostatic cancer were treated conservatively with Turisteron at a dosage of 2 mg per week. After 2 months the serum levels of total testosterone were reduced to castration values and thereafter furthermore to 6% of the pretreatment values. The free testosterone (FT) serum level did show a decrease to 2%, while the binding capacity of the sexual hormone binding globulin (SHBG) was increased from 4,1% to 97,9%. The serum levels of the two gonadotropic hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH) were decreased only to nearly 20% of the pretreatment value. The investigations confirm the definite "antiandrogenic" effect of Turisteron, which is 10-times higher than the antigonadotropic effect.

• Authors: H M Guddat, D Schnorr, G Dörner, F Stahl, W Rohde
• Journal: Zeitschrift fur Urologie und Nephrologie (Z Urol Nephrol) Vol. 80 Issue 12 Pg. 665-8 (Dec 1987) ISSN: 0044-3611 [Print] Germany
• Vernacular Title: Das Verhalten der Serumspiegel von LH, FSH, Gesamttestosteron (GT), freiem Testosteron (FT) und SHBG unter der Therapie des Prostatakarzinoms mit Turisteron (Ethinylestradiolsulfonat).
• PMID: 3126615 (Publication Type: English Abstract, Journal Article)

Chemical References

• Gonadal Steroid Hormones
• Sex Hormone-Binding Globulin
• ethinyl estradiol sulfonate
• Testosterone
• Ethinyl Estradiol
• Luteinizing Hormone
• Follicle Stimulating Hormone

Topics

• Ethinyl Estradiol (analogs & derivatives, therapeutic use)
• Follicle Stimulating Hormone (blood)
• Follow-Up Studies
• Gonadal Steroid Hormones (blood)
• Humans
• Luteinizing Hormone (blood)
• Male
• Prostatic Neoplasms (blood, drug therapy)
• Sex Hormone-Binding Globulin (metabolism)
• Testosterone (blood)