HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Inhibition of v-fms-induced tumor growth in nude mice by castanospermine.

Abstract
Castanospermine, an indolizidine alkaloid isolated from the seeds of the chestnut tree Castanospermum australe, has been shown to prevent the normal glycosylational processing of the v-fms-transforming glycoprotein. v-fms-transformed cells grown in vitro in the presence of castanospermine accumulate immature forms of the glycoprotein that do not reach the cell surface. These treated cells revert to the normal phenotype. We have now extended those studies to an in vivo tumorigenicity model in the nude mouse using v-fms-transformed rat cells (SM-FRE) and dietary administration of castanospermine. Following tumor induction with s.c. injection of 10(6) SM-FRE cells, mice whose diet had been supplemented with 2.4 mg castanospermine/g food consumed approximately 0.84 mg castanospermine/g mouse/day. Furthermore, these mice had slower growing tumors that were 2.6 times smaller than tumors in control groups at the termination of the experiment 24 days postinjection. These results indicate that castanospermine is effective in slowing the growth of v-fms-transformed cells in vivo, suggesting that this drug may offer an effective therapy against certain tumors, including some arising from activated protooncogenes that encode glycoproteins such as growth factor receptors.
AuthorsG K Ostrander, N K Scribner, L R Rohrschneider
JournalCancer research (Cancer Res) Vol. 48 Issue 5 Pg. 1091-4 (Mar 01 1988) ISSN: 0008-5472 [Print] United States
PMID3124955 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Alkaloids
  • Glycoproteins
  • Indolizines
  • Oncogene Protein gp140(v-fms)
  • Retroviridae Proteins
  • Glucosidases
  • beta-Glucosidase
  • castanospermine
Topics
  • Alkaloids (therapeutic use)
  • Animals
  • Body Weight (drug effects)
  • Eating (drug effects)
  • Female
  • Glucosidases (antagonists & inhibitors)
  • Glycoproteins (genetics)
  • Indolizines
  • Mice
  • Mice, Inbred BALB C
  • Mice, Nude
  • Neoplasms, Experimental (drug therapy, pathology)
  • Oncogene Protein gp140(v-fms)
  • Retroviridae Proteins (genetics)
  • beta-Glucosidase (antagonists & inhibitors)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: