HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Enkephalinase inhibitors attenuate naloxone-precipitated withdrawal syndrome.

Abstract
Enkephalinase inhibitors phosphoramidon, thiorphan or phelorphan suppressed naloxone-precipitated withdrawal symptoms in acute and chronic morphine dependent mice and rats. It is suggested that decreased biotransformation of the endogenous opioid peptides might compensate the relative shortage of exogenous opiates during withdrawal in opiate dependent subjects and could be a new and promising way to attenuate the severity of abstinential syndrome.
AuthorsM R Dzoljic
JournalNIDA research monograph (NIDA Res Monogr) Vol. 75 Pg. 575-8 ( 1986) ISSN: 1046-9516 [Print] United States
PMID3123978 (Publication Type: Journal Article)
Chemical References
  • Amino Acids, Sulfur
  • Dipeptides
  • Glycopeptides
  • phelorphan
  • Naloxone
  • Thiorphan
  • Tiopronin
  • Metalloendopeptidases
  • Neprilysin
  • phosphoramidon
Topics
  • Amino Acids, Sulfur (pharmacology)
  • Animals
  • Cerebral Ventricles (drug effects, physiopathology)
  • Cerebrospinal Fluid (physiology)
  • Dipeptides (pharmacology)
  • Glycopeptides (pharmacology)
  • Male
  • Metalloendopeptidases (antagonists & inhibitors)
  • Mice
  • Mice, Inbred Strains
  • Morphine Dependence (physiopathology)
  • Naloxone (adverse effects, pharmacology)
  • Neprilysin
  • Rats
  • Rats, Inbred Strains
  • Stereotyped Behavior (drug effects)
  • Substance Withdrawal Syndrome
  • Thiorphan
  • Tiopronin (analogs & derivatives, pharmacology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: