Abstract | AIM: METHODS: Data of 1270 patients who underwent initial hepatectomy for hepatocellular carcinoma between 1986 and 2016 were retrospectively collected from a multi-institutional database. The prognostic impact of each system was analyzed according to the results of the area under the receiver operating characteristic curve, the Cox regression model and the linear trend χ2 -test. RESULTS: The ALBI and ALICE scores, which were obtained before grading status, were significantly correlated (correlation coefficient 0.930; P < 0.001). Both ALBI and ALICE grades stratified well in terms of overall survival, and were found to be independent prognostic factors on multivariate analysis (P < 0.05). The area under the receiver operating characteristic curves for 5-year survival in both groups were equivalent (0.602 vs. 0.614, P = 0.402); however, homogeneity, discriminatory ability, and the Akaike information criterion were superior for the ALICE grade than for the ALBI grade (73.8 vs. 65.7, 43.4 vs. 34.9, and 7204.1 vs. 7212.2, respectively). CONCLUSIONS: Both grading systems could estimate the liver function of patients with hepatocellular carcinoma. Regarding hepatectomy patients, the ALICE grade was a more suitable model than the ALBI grade.
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Authors | Naruhiko Honmyo, Tsuyoshi Kobayashi, Michinori Hamaoka, Toshihiko Kohashi, Tomoyuki Abe, Koichi Oishi, Hirofumi Tazawa, Yasuhiro Imaoka, Tomoyuki Akita, Junko Tanaka, Hideki Ohdan, Hiroshima Surgical study group of Clinical Oncology (HiSCO) |
Journal | Hepatology research : the official journal of the Japan Society of Hepatology
(Hepatol Res)
Vol. 49
Issue 10
Pg. 1218-1226
(Oct 2019)
ISSN: 1386-6346 [Print] Netherlands |
PMID | 31237074
(Publication Type: Journal Article)
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Copyright | © 2019 The Japan Society of Hepatology. |