Duct-obstructive pancreatitis with granulocytic epithelial lesion in a patient with ulcerative colitis: An atypical manifestation of type 2 autoimmune pancreatitis?

Abstract

Type 2 autoimmune pancreatitis (AIP) typically presents with diffuse or focal enlargement of the pancreas; however, its diverse clinical presentation has not yet been clarified. We herein described a 46-year-old man with a 1-month history of ulcerative colitis who presented with imaging features of a mass-like lesion in the pancreatic body with upstream duct dilatation and serum CA19-9 elevation. He underwent laparoscopic distal pancreatectomy with splenectomy for suspected malignancy. Histologically, the area radiologically suspected to be duct dilatation consisted of necrotic tissue, in which the disrupted main pancreatic duct was involved. The area radiologically suspected to be the mass lesion showed features of pancreatitis without discrete mass. In addition, several ducts showed neutrophilic duct injury similar to granulocytic epithelial lesions observed in type 2 AIP. Immunohistochemistry revealed the aberrant expression of IL-8 in the pancreatic ductules and infiltrating CD3-positive T-lymphocytes, findings recently identified in type 2 AIP. The present case is not typical for either type 2 AIP or other known conditions, but extreme examples of type 2 AIP may present with ductal obstruction because of severe neutrophilic duct injury. IL-8 immunostaining may also assist in establishing a diagnosis of type 2 AIP with an atypical presentation.

• Authors: Soomin Ahn, Jong-Chan Lee, Jin-Hyeok Hwang, Yoo-Seok Yoon, Kyoung Ho Lee, Yoh Zen
• Journal: Pathology international (Pathol Int) Vol. 69 Issue 7 Pg. 420-426 (Jul 2019) ISSN: 1440-1827 [Electronic] Australia
• PMID: 31219205 (Publication Type: Case Reports)
• Copyright: © 2019 Japanese Society of Pathology and John Wiley & Sons Australia, Ltd.

Topics

• Autoimmune Diseases (pathology)
• Autoimmune Pancreatitis (diagnosis, pathology)
• Colitis, Ulcerative (diagnosis, pathology)
• Granulocytes (pathology)
• Humans
• Male
• Middle Aged
• Pancreas (pathology)
• Pancreatic Ducts (pathology)