Anti-interferon-gamma antibody protects mice against the generalized Shwartzman reaction.

A generalized Shwartzman reaction was found to occur in non-SPF-NMRI mice given a local injection of S. marcescens lipopolysaccharide (LPS) in the footpad, followed, with an interval of 24 h, by an i.v. injection. The reaction occurred several hours after the second injection. It was characterized by disseminated subcutaneous bleedings at the mouth, anus, conjuctiva, nose tip and tail end. Most mice died within 24-48 h. The size of the LPS dose given in the footpad (5 micrograms) was found to be critical in that the reaction failed to occur with higher as well as lower doses. The reaction was found to be completely absent in mice that had received one or more systemic injections of monoclonal antibodies with neutralizing potential for murine interferon-gamma (IFN-gamma). Mice treated with control preparations, including a monoclonal antibody with binding but no neutralizing activity for murine IFN-gamma, remained sensitive to induction of the reaction. These observations assign a crucial role to endogenous IFN-gamma in the elicitation of the generalized Shwartzman reaction and open perspectives for the prevention or therapy of clinical conditions related to the Shwartzman reaction by the use of antibodies to IFN-gamma.
AuthorsA Billiau, H Heremans, F Vandekerckhove, C Dillen
JournalEuropean journal of immunology (Eur J Immunol) Vol. 17 Issue 12 Pg. 1851-4 (Dec 1987) ISSN: 0014-2980 [Print] GERMANY, WEST
PMID3121360 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antibodies, Monoclonal
  • Lipopolysaccharides
  • Interferon-gamma
  • Animals
  • Antibodies, Monoclonal
  • Antigen-Antibody Reactions
  • Female
  • Interferon-gamma (immunology)
  • Lipopolysaccharides (immunology)
  • Mice
  • Neutralization Tests
  • Serratia marcescens (immunology)
  • Shwartzman Phenomenon

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: