Abstract | INTRODUCTION: CASE AND OUTCOMES: In this report, a 69-year-old male presented with progressive extensive truncal PCALCL resistant to brentuximab. The truncal lesions were treated with 36 Gy in 18 fractions by a novel approach using rotational electron beam radiation therapy with custom-made shielding. The treatment was well tolerated with expected dermatologic side effects managed supportively. All lesions achieved an initial complete response, and two sites within the treatment field recurred five months after treatment. DISCUSSION: This case adds to the limited literature on diffuse PCALCL and demonstrates an uncommon treatment approach to multifocal PCALCL using rotational electron beam radiation therapy with personalized shielding techniques. The treatment approach here was well tolerated by the patient with initial complete response at all sites. Maximal sparing was especially critical in this patient because of a history of previous head and neck irradiation. Shielded areas were validated by optically stimulated luminescent dosimeters showing dose reduction, confirming the utility of this method. CONCLUSION: Rotational total skin electron beam with personalized shielding may be generalizable to cutaneous malignancies including PCALCL presenting with diffuse skin involvement. Further investigation of diffuse PCALCL is merited to optimize treatment strategies.
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Authors | Alexander D Sherry, George X Ding, Austin N Kirschner |
Journal | Journal of medical imaging and radiation sciences
(J Med Imaging Radiat Sci)
Vol. 50
Issue 3
Pg. 454-459
(Sep 2019)
ISSN: 1876-7982 [Electronic] United States |
PMID | 31213358
(Publication Type: Case Reports, Journal Article)
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Copyright | Copyright © 2019. Published by Elsevier Inc. |
Topics |
- Aged
- Humans
- Lymphoma, Primary Cutaneous Anaplastic Large Cell
(radiotherapy)
- Male
- Radiation Protection
(methods)
- Radiometry
(methods)
- Radiotherapy
(methods)
- Skin Neoplasms
(radiotherapy)
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