Abstract | BACKGROUND: OBJECTIVE: To investigate the long-term efficacy and safety of rupatadine in the management of pruritus, and the clinical effect of updosing to 20mg in Japanese adult and adolescent patients. METHODS: RESULTS: The mean [95% CI] change from baseline to Week 2 in the total pruritus score was -1.241 [-1.450, -1.033] (paired t test, P< 0.001). The therapeutic effect persisted up to Week 52 (paired t test, P< 0.001). Adverse drug reactions (ADRs) were reported at an overall incidence of 18.0% (45 events in 37 patients). No serious or clinically significant ADRs were reported. Somnolence was the most common ADR (14.1%). CONCLUSIONS:
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Authors | Michihiro Hide, Takamasa Suzuki, Ayaka Tanaka, Hiroshi Aoki |
Journal | Journal of dermatological science
(J Dermatol Sci)
Vol. 94
Issue 3
Pg. 339-345
(Jun 2019)
ISSN: 1873-569X [Electronic] Netherlands |
PMID | 31196788
(Publication Type: Clinical Trial, Phase III, Journal Article, Multicenter Study)
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Copyright | Copyright © 2019 The Authors. Published by Elsevier B.V. All rights reserved. |
Chemical References |
- Histamine H1 Antagonists, Non-Sedating
- rupatadine
- Cyproheptadine
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Topics |
- Adolescent
- Adult
- Child
- Chronic Urticaria
(complications, drug therapy)
- Cyproheptadine
(administration & dosage, analogs & derivatives)
- Dose-Response Relationship, Drug
- Eczema
(complications, drug therapy)
- Female
- Histamine H1 Antagonists, Non-Sedating
(administration & dosage, adverse effects)
- Humans
- Japan
- Male
- Middle Aged
- Pruritus
(diagnosis, drug therapy, etiology)
- Severity of Illness Index
- Sleepiness
- Time Factors
- Treatment Outcome
- Young Adult
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