[Teratological study of 4-ethoxy-2-methyl 5-morpholino-3(2H)-pyridazinone (M73101) in mice and rats (author's transl)].

M73101 was given orally to pregnant mice (0, 100, 400 and 800 mg/kg/day) and rats (0, 100, 300 and 600mg/kg/day) during the major organogenesis to assess the influences of prenatal and postnatal development of progeny. There were no apparent effects of M73101 on litter size, fetal mortality or sex ratio in both species, although slight decrease in body weight occurred in fetuses of mice and rats exposed to the largest dose. No external, internal or skeletal malformations attributable to M73101 were observed in mouse and rat fetuses. No apparent influences of M73101 on postnatal development of mouse or rat offspring were seen.
AuthorsH Tanigawa, T Kosazuma, H Tanaka, R Obori
JournalThe Journal of toxicological sciences (J Toxicol Sci) Vol. 3 Issue 1 Pg. 69-86 (Feb 1978) ISSN: 0388-1350 [Print] JAPAN
PMID311855 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Anti-Inflammatory Agents, Non-Steroidal
  • Morpholines
  • Pyridazines
  • Teratogens
  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal (toxicity)
  • Body Weight (drug effects)
  • Dose-Response Relationship, Drug
  • Female
  • Fetal Death (chemically induced)
  • Litter Size (drug effects)
  • Male
  • Mice
  • Morpholines (toxicity)
  • Pregnancy
  • Pyridazines (toxicity)
  • Rats
  • Sex Ratio
  • Teratogens

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