[Effect of glutathione on the course of radiation sickness with a marked gastrointestinal syndrome and the effectiveness of parenteral feeding in an experiment].

Abstract

Injections of oxidized glutathione (40 mg/kg, 5-7 days) combined with the parenteral nutrition (PN) of rats after local X-irradiation of abdomen (13-14.5 Gy) increased significantly the survival rate, decreased the gastrointestinal syndrome manifestations, and intensified the assimilation of a PF amino acid component. The reduced glutathione had no effect.

• Authors: S P Grozdov
• Journal: Radiobiologiia (Radiobiologiia) 1987 Sep-Oct Vol. 27 Issue 5 Pg. 657-62 ISSN: 0033-8192 [Print] Russia (Federation)
• Vernacular Title: Vliianie glutationa na techenie luchevoĭ bolezni s vyrazhennym zheludochno-kishechnym sindromom i na éffektivnost' parenteral'nogo lecheniia v éksperimente.
• PMID: 3118407 (Publication Type: English Abstract, Journal Article)

Chemical References

• Amino Acids
• Glutathione
• Nitrogen

Topics

• Acute Disease
• Amino Acids (metabolism)
• Animals
• Gastrointestinal Diseases (etiology, metabolism, therapy)
• Glutathione (metabolism, therapeutic use)
• Male
• Nitrogen (metabolism)
• Oxidation-Reduction
• Parenteral Nutrition
• Radiation Injuries, Experimental (complications, metabolism, mortality, therapy)
• Rats
• Rats, Inbred Strains