Anticonvulsant effect of denzimol in DBA/2 mice.

Abstract

The anticonvulsant activity of N-[beta-[4-beta-phenylethyl)phenyl]-beta-hydroxyethyl]-imidazole hydrochloride, denzimol, was studied following intraperitoneal administration in DBA/2 mice (seizures induced by sound). Protection against sound-induced seizures was observed after intraperitoneal administration of denzimol (3-15 mg/kg). The ED50 values for the suppression of tonic, clonic and wild running phases of sound-induced seizures were 1.24, 2.61 and 6.03 mg/kg, respectively. This protective action was significantly reduced by pretreatment with aminophylline (25 mg/kg i.p.), CGS 8216 (1 or 5 mg/kg i.p.) and Ro 15-1788 (2.5 mg/kg i.p). The present experiments suggest an involvement of purinergic and benzodiazepine mechanisms in the anticonvulsant action of denzimol.

• Authors: G B De Sarro, V Libri, C Ascioti, R Testa, G Nistico
• Journal: Neuropharmacology (Neuropharmacology) Vol. 26 Issue 9 Pg. 1425-9 (Sep 1987) ISSN: 0028-3908 [Print] England
• PMID: 3118235 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anticonvulsants
• Imidazoles
• Pyrazoles
• Aminophylline
• Flumazenil
• 2-phenylpyrazolo(4,3-c)quinolin-3(5H)-one
• denzimol

Topics

• Acoustic Stimulation
• Aminophylline (pharmacology)
• Animals
• Anticonvulsants (pharmacology)
• Flumazenil (pharmacology)
• Imidazoles (pharmacology)
• Mice
• Mice, Inbred DBA
• Pyrazoles (pharmacology)
• Seizures (prevention & control)