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Tizanidine hydrochloride exhibits a cytotoxic effect on osteosarcoma cells through the PI3K/AKT signaling pathway.

AuthorsXue-Wu Xing, Yu-Fu Sun, Jun Zhao, Zi-Xiang Pan, Wen-Xue Jiang
JournalThe Journal of international medical research (J Int Med Res) Vol. 47 Issue 8 Pg. 3792-3802 (Aug 2019) ISSN: 1473-2300 [Electronic] England
PMID31179788 (Publication Type: Journal Article)
Chemical References
  • Anticonvulsants
  • tizanidine
  • Proto-Oncogene Proteins c-akt
  • Clonidine
Topics
  • Anticonvulsants (pharmacology)
  • Bone Neoplasms (drug therapy, metabolism, pathology)
  • Cell Movement
  • Cell Proliferation (drug effects)
  • Clonidine (analogs & derivatives, pharmacology)
  • Gene Expression Regulation, Neoplastic (drug effects)
  • Humans
  • Osteosarcoma (drug therapy, metabolism, pathology)
  • Phosphatidylinositol 3-Kinases (genetics, metabolism)
  • Proto-Oncogene Proteins c-akt (genetics, metabolism)
  • Signal Transduction
  • Tumor Cells, Cultured

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