HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Amniotic membrane production of prostaglandin F2 alpha is reduced in dysfunctional human labor: results of in vivo and in vitro studies.

Abstract
Mobilization of arachidonic acid from glycerophospholipids and prostaglandin (PG) release from fetal membranes were studied in women with dysfunctional labor in the absence of cephalopelvic disproportion or fetal malposition. Using superfusion of intact amnion and chorion, we found a slight decrease in PGE and a more significant decrease in PGF release by the amniotic side of the fetal membrane obtained from women with dysfunctional labor compared to that in women with normal labor (PGE: normal labor, 2992 pg/cm2.h; dysfunctional labor, 1846 pg/cm2.h; P less than 0.05; PGF: normal labor, 662 pg/cm2.h; dysfunctional labor, 204 pg/cm2.h; P less than 0.02). Release of both prostanoids was significantly greater from the amniotic side in tissues obtained after labor compared to that in prelabor tissue. Analysis of arachidonic acid (by gas liquid chromatography) and phospholipid content (by two-dimensional thin layer chromatography) confirmed metabolic disposal of arachidonic acid from the amnion after the onset of labor. However, no difference in either phospholipid or phospholipase A2-releasable arachidonic acid of individual phospholipid classes was found in amnion tissue from women with normal and dysfunctional labor, suggesting similar activities of phospholipase A2 in these two groups. The finding of decreased free and phospholipase A2-releasable arachidonic acid of the total lipid extract of the amnion of women with dysfunctional labor could suggest further metabolic exhaustion of the substrate or failure of liberation of this fatty acid from glycerophospholipids by enzymes other than phospholipase A2, such as phospholipase C or diacyl and monoacylglycerolipases.
AuthorsK Reddi, R J Norman, W M Deppe, C T Machattie, M Kemp, S M Joubert
JournalThe Journal of clinical endocrinology and metabolism (J Clin Endocrinol Metab) Vol. 65 Issue 5 Pg. 1000-5 (Nov 1987) ISSN: 0021-972X [Print] UNITED STATES
PMID3117829 (Publication Type: Journal Article)
Chemical References
  • Arachidonic Acids
  • Lipids
  • Phospholipids
  • Prostaglandins
  • Prostaglandins F
  • Arachidonic Acid
  • Dinoprost
Topics
  • Adult
  • Amnion (analysis, metabolism)
  • Amniotic Fluid (metabolism)
  • Arachidonic Acid
  • Arachidonic Acids (analysis, metabolism)
  • Dinoprost
  • Female
  • Humans
  • Lipids (analysis)
  • Obstetric Labor Complications (metabolism)
  • Osmolar Concentration
  • Phospholipids (analysis)
  • Pregnancy
  • Prostaglandins (metabolism)
  • Prostaglandins F (biosynthesis)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: