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[Acute liver and kidney failure following sorbitol infusion in a 28-year-old patient with undiagnosed fructose intolerance].

Abstract
In connection with nephrectomy fatal liver and renal failure occurred after infusion of 50 g sorbitol in a 28 years old patient with undiagnosed fructose intolerance. A marked hypoglycemia and lactacidosis, an increase in uric acid, an acute liver failure with breakdown of excretory and synthetic function and disorder of hemostasis were typical of fructose/sorbitol infusion in hereditary fructose intolerance. Under adequate diet, as indicated in our case, HFI could be undiagnosed up to adult age. Therefore, fructose intolerance should be excluded by anamnesis before infusion of fructose/sorbitol. In unknown anamnesis (unconsciousness) fructose/sorbitol containing infusions should not be used. Fructose/sorbitol containing infusions should not be given routinely, but only with certain indication.
AuthorsS Locher
JournalAnasthesie, Intensivtherapie, Notfallmedizin (Anasth Intensivther Notfallmed) Vol. 22 Issue 4 Pg. 194-7 (Aug 1987) ISSN: 0174-1837 [Print] Germany
Vernacular TitleAkutes Leber- und Nierenversagen nach Sorbitinfusion bei 28jährigem Patienten mit undiagnostizierter Fruktoseintoleranz.
PMID3116878 (Publication Type: Case Reports, English Abstract, Journal Article)
Chemical References
  • Sorbitol
Topics
  • Abscess (surgery)
  • Acute Kidney Injury (chemically induced)
  • Adult
  • Carbohydrate Metabolism, Inborn Errors (complications)
  • Fructose Intolerance (complications, diagnosis)
  • Hepatic Encephalopathy (chemically induced)
  • Humans
  • Kidney Diseases (surgery)
  • Male
  • Nephrectomy
  • Parenteral Nutrition, Total
  • Sorbitol (administration & dosage, adverse effects)

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