Abstract | BACKGROUND: METHOD: ANGPTL4 genotypes were determined using a TaqMan genotyping based real time PCR method. The association of the genetic variant with the risk of metabolic syndrome and its relationship with lipid profile were determined. RESULT: The frequency of GG, GA and AA genotypes were 96.9, 2.7 and 0.4% in individuals with MetS, and 78.8, 20.8, 0.4%, in those without MetS. The GA genotype of the rs116843064 polymorphism was associated with a lower risk for MetS (e.g., OR in Codominant genetic model: 0.14, 95% CI: (0.06-0.33), p < 0.0001). Subject with an A allele had a higher risk for MetS (OR: 6.72, 95% CI: (3.05-14.82), p < 0.0001). There was a significant difference in fasted lipid profiles across the genotypes for ANGPTL4. Carriers of the AG genotype had higher levels of serum HDL-cholesterol (HDL-C) and lower TG, compared to the GG homozygotes genotype. CONCLUSION: The G allele at the rs116843064 polymorphic locus of the ANGPTL4 gene was associated with a lower prevalence of MetS.
|
Authors | Sara Kharazmi-Khorassani, Jasmin Kharazmi-Khorassani, Azam Rastegar-Moghadam, Sara Samadi, Hamideh Ghazizadeh, Maryam Tayefi, Gordon A Ferns, Majid Ghayour-Mobarhan, Amir Avan, Habibollah Esmaily |
Journal | BMC medical genetics
(BMC Med Genet)
Vol. 20
Issue 1
Pg. 97
(06 04 2019)
ISSN: 1471-2350 [Electronic] England |
PMID | 31164103
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- ANGPTL4 protein, human
- Angiopoietin-Like Protein 4
- Triglycerides
|
Topics |
- Adult
- Alleles
- Angiopoietin-Like Protein 4
(genetics)
- Atherosclerosis
(blood, genetics)
- Cohort Studies
- Female
- Gene Frequency
- Genetic Predisposition to Disease
(genetics)
- Genotype
- Humans
- Male
- Metabolic Syndrome
(blood, genetics)
- Middle Aged
- Polymorphism, Single Nucleotide
- Risk Factors
- Triglycerides
(blood)
|