Reticuloendothelial system Fc receptor function in systemic lupus erythematosus: effect of decreased sensitization on clearance of autologous erythrocytes.

Abstract

Recent reports of reticuloendothelial system Fc receptor function using anti-Rh(D) coated red blood cells (RBC) provide conflicting data regarding the degree of abnormality in systemic lupus erythematosus (SLE). The effect of different sensitizing doses of anti-Rh(D) on Fc receptor function was evaluated in 10 controls and 9 patients with SLE (5 with renal disease, 4 without) using 1 microgram anti-Rh(D) (6,700 molecules anti-Rh(D)/RBC by saturation analysis) and 0.125 microgram anti-Rh(D) (1,100 molecules/RBC). At the lower sensitizing dose the sensitivity of the assay was significantly increased. To correctly interpret the significance of studies of Fc receptor function from different centers, it is necessary to know the exact sensitizing doses used for each study.

• Authors: L Kabbash, J Esdaile, S Shenker, F Decary, D Danoff, A Fuks, J Shuster
• Journal: The Journal of rheumatology (J Rheumatol) Vol. 14 Issue 3 Pg. 487-9 (Jun 1987) ISSN: 0315-162X [Print] Canada
• PMID: 3114484 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Isoantibodies
• Receptors, Fc
• Rh-Hr Blood-Group System

Topics

• Adult
• Erythrocytes (immunology)
• Female
• Humans
• Isoantibodies
• Lupus Erythematosus, Systemic (immunology)
• Male
• Middle Aged
• Mononuclear Phagocyte System (immunology)
• Receptors, Fc (physiology)
• Rh-Hr Blood-Group System