Importance of L3T4+ and Lyt-2+ cells in the immunologic control of infection with Mycobacterium bovis strain bacillus Calmette-Guérin in mice. Assessment by elimination of T cell subsets in vivo.

Abstract

The course of infection after injection of small doses of bacillus Calmette-Guérin (BCG) was studied in mice which were depleted in vivo of T cell subsets by administration of either anti-L3T4 or anti-Lyt-2 mAb. The results presented herein strongly suggest that the L3T4+ subpopulation play a pivotal role in the immunologic control of BCG infection because the depletion of L3T4+ cells led to a dramatic increase in the number of viable bacteria. Depletion of Lyt-2+ cells had no significant effect on the course of infection. These results were confirmed by using adoptive transfer experiments which showed that protective immunity was mediated by L3T4+ cells generated in the spleen as a result of infection. Moreover, T cells capable of controlling the recurrence of BCG multiplication from residual bacteria remaining in organs after the recovery from infection were shown to belong to the L3T4+ subpopulation.

• Authors: T Pedrazzini, K Hug, J A Louis
• Journal: Journal of immunology (Baltimore, Md. : 1950) (J Immunol) Vol. 139 Issue 6 Pg. 2032-7 (Sep 15 1987) ISSN: 0022-1767 [Print] United States
• PMID: 3114383 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antibodies, Monoclonal
• Antigens, Differentiation, T-Lymphocyte
• Antigens, Ly
• Antigens, Surface

Topics

• Animals
• Antibodies, Monoclonal
• Antigens, Differentiation, T-Lymphocyte
• Antigens, Ly (immunology)
• Antigens, Surface (immunology)
• Immunization, Passive
• Mice
• Mycobacterium bovis (immunology)
• Spleen (immunology)
• T-Lymphocytes (classification, immunology)
• Time Factors
• Tuberculosis (veterinary)