Expression of neural-tissue markers (S-100 protein and Leu-7 antigen) by sweat gland tumors of the skin. An immunohistochemical study.

Abstract

The expression of two immunohistochemical markers of neural tissue and of cutaneous sweat glands (S-100 protein and Leu-7 antigen) was studied in a group of cutaneous epithelial, mostly glandular, tumors. These antigens were detected only on sweat gland neoplasms showing both types (eccrine and apocrine) of differentiation. These results suggest that antibodies to S-100 protein and to Leu-7 antigen have a limited value in the distinction between eccrine and apocrine tumours, but they may serve as a useful adjunct for the confirmation of the glandular differentiation of cutaneous epithelial tumors.

• Authors: J Kanitakis, G Zambruno, J Viac, H Panzini, J Thivolet
• Journal: Journal of the American Academy of Dermatology (J Am Acad Dermatol) Vol. 17 Issue 2 Pt 1 Pg. 187-91 (Aug 1987) ISSN: 0190-9622 [Print] United States
• PMID: 3114335 (Publication Type: Journal Article)

Chemical References

• Antigens, Differentiation, T-Lymphocyte
• Antigens, Surface
• S100 Proteins

Topics

• Antigens, Differentiation, T-Lymphocyte
• Antigens, Surface (analysis)
• Diagnosis, Differential
• Humans
• Immunoenzyme Techniques
• Retrospective Studies
• S100 Proteins (analysis)
• Sweat Gland Neoplasms (analysis, immunology, pathology)