Dopamine, the kidney and essential hypertension studies with gludopa.

Abstract

The formation and action of intrarenal dopamine is reviewed, as also is the evidence for the use of gamma-L-glutamyl-L-dopa as a relatively renally specific dopaminergic pro-drug. 'Salt sensitive' patients with essential hypertension may have a fault in the renal mobilisation of dopamine by sodium chloride. This failure of sodium to dopamine coupling may be particularly prevalent in the Negro race.

• Authors: M R Lee
• Journal: Clinical and experimental hypertension. Part A, Theory and practice (Clin Exp Hypertens A) Vol. 9 Issue 5-6 Pg. 977-86 ( 1987) ISSN: 0730-0077 [Print] United States
• PMID: 3113781 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• gamma-glutamyl DOPA
• Dihydroxyphenylalanine
• Dopamine

Topics

• Dihydroxyphenylalanine (analogs & derivatives, pharmacology)
• Dopamine (metabolism)
• Humans
• Hypertension (physiopathology)
• Kidney (metabolism)